Dimethyl Sulfoxide → HCID 68773319, compound

HRID 1172352Notes

Reaction equation

C=[C:2]([CH2:7][CH:8]([N+:22]([O-:24])=[O:23])[CH:9]([C:13]1[CH:18]=[C:17]([F:19])[C:16]([F:20])=[CH:15][C:14]=1[F:21])[CH2:10][CH:11]=C)[C:3]([O:5][CH3:6])=[O:4].C(N(CC)CC)C.CS(C)=O>ClCCCl.Cl[Ru](=C1N(C2C(C)=CC(C)=CC=2C)CCN1C1C(C)=CC(C)=CC=1C)(Cl)(=CC1C=CC=CC=1)[P](C1CCCCC1)(C1CCCCC1)C1CCCCC1>[N+:22]([C@@H:8]1[CH2:7][C:2]([C:3]([O:5][CH3:6])=[O:4])=[CH:11][CH2:10][C@H:9]1[C:13]1[CH:18]=[C:17]([F:19])[C:16]([F:20])=[CH:15][C:14]=1[F:21])([O-:24])=[O:23]

Participants

Conditions

Temperature: 55 °C

Procedure

A stream of dinitrogen gas was bubbled through a mechanically-stirred solution of methyl 2-methylene-4-nitro-5-(2,4,5-trifluorophenyl)oct-7-enoate (98 g, 285.7 mmol, 1:1 mixture of erythro and threo isomers) in DCE (1.43 L) at 70° C. A solution of Grubbs' 2nd generation catalyst (9.7 g, 11.4 mmol) in DCE (61 mL) was added via syringe pump over about twelve hours. The reaction was then cooled to 55° C., and triethylamine (3.98 mL, 28.6 mmol) was added. After eight hours, the heating bath was removed, and DMSO (64 mL, 912 mmol) was added to the reaction. After stirring for twelve hours, the reaction was concentrated under reduced pressure, and the crude residue was purified by MPLC on SiO2 gel (15% EtOAc in Hx) to give the title compound as a dark waxy solid (63 g, 72%). 1H NMR (300 MHz, CDCl3) δ ppm 7.06-6.90 (m, 3H), 5.03 (ddd, J=5.8, 10.5 and 10.5 Hz, 1H), 3.79 (s, 3H), 3.64 (ddd, J=6.1, 10.5, and 10.5 Hz, 1H), 3.20-3.12 (m, 1H), 3.01-2.89 (m, 1H), 2.80-2.70 (m, 1H), 2.63-2.51 (m, 1H).

Workup

customthe heating bath was removed
concentrationthe reaction was concentrated under reduced pressure
customthe crude residue was purified by MPLC on SiO2 gel (15% EtOAc in Hx)

Sources & evidence

ORD record: ord-525b509262f7419a82bab5b0f2c73623
Source dataset: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07834012B2

Reaction notes

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