Tetrahydrofuran → Tert-butyl 4-(4-chloro-2-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)phenyl)-4-hydroxypiperidine-1-carboxylate

HRID 117244Notes

Reaction equation

HRID 117244 reaction equation
[Br:1][c:2]1[c:3]([C:9]2=[N:13][C:12]([CH3:14])([CH3:15])[CH2:11][O:10]2)[cH:4][c:5]([Cl:8])[cH:6][cH:7]1.[C:21]([CH3:22])([CH3:23])([CH3:24])[O:25][C:26](=[O:27])[N:28]1[CH2:29][CH2:30][C:31](=[O:34])[CH2:32][CH2:33]1.[CH2:16]([Li:17])[CH2:18][CH2:19][CH3:20].[O:35]1[CH2:36][CH2:37][CH2:38][CH2:39]1>>[c:2]1([C:31]2([OH:34])[CH2:30][CH2:29][N:28]([C:26]([O:25][C:21]([CH3:22])([CH3:23])[CH3:24])=[O:27])[CH2:33][CH2:32]2)[c:3]([C:9]2=[N:13][C:12]([CH3:14])([CH3:15])[CH2:11][O:10]2)[cH:4][c:5]([Cl:8])[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 231369142-(2-Bromo-5-chlorophenyl)-4,4-dimethyl-4,5-dihydrooxazoleHCID 178418339Butyllithium

Product 1

HCID 46835566Tert-butyl 4-(4-chloro-2-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)phenyl)-4-hydroxypiperidine-1-carboxylate

Sources & evidence

ORD record
ord-1e05bcab0a8640559362196c08361ea0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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