HCID 12767831, compound → 2-Propyl-4-(4-chlorophenoxy)phenol

HRID 1172810Notes

Reaction equation

HRID 1172810 reaction equation
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([OH:13])=[C:9]([CH2:14][CH:15]=[CH2:16])[CH:8]=2)=[CH:4][CH:3]=1>C(OCC)(=O)C.[Pd]>[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([OH:13])=[C:9]([CH2:14][CH2:15][CH3:16])[CH:8]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 12767831HCID 12767831, compound

Product 1

HCID 187722622-Propyl-4-(4-chlorophenoxy)phenolYield 99.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of the product from step 4 (15.7 g, 60 mmol) and 10% Pd/C (3.1 g) in ethyl acetate (300 mL) was stirred under hydrogen (1 atm). After the reaction was completed (ca. 30 min), the mixture was filtered through celite and the filtrate was concentrated to give 15.7 g of the title compound as an oil which solidified upon standing.

Workup

  1. custom(ca. 30 min)
  2. filtrationthe mixture was filtered through celite
  3. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-e571cbcda72748c38d02b2a2e1494a82
Source dataset
uspto-grants-2010_11
Patent number
US07834036B2

Reaction notes

Loading…