Cesium carbonate → HCID 68693637, compound

HRID 1172819Notes

Reaction equation

HRID 1172819 reaction equation
[Cl:1][C:2]1[CH:29]=[CH:28][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10](/[C:13](/[C:16]3[CH:21]=[C:20]([O:22][CH3:23])[CH:19]=[CH:18][C:17]=3F)=[N:14]/[OH:15])=[C:9]([CH2:25][CH2:26][CH3:27])[CH:8]=2)=[CH:4][CH:3]=1.C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C=O)C.C(OCC)(=O)C>[Cl:1][C:2]1[CH:29]=[CH:28][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([C:13]3[C:16]4[CH:21]=[C:20]([O:22][CH3:23])[CH:19]=[CH:18][C:17]=4[O:15][N:14]=3)=[C:9]([CH2:25][CH2:26][CH3:27])[CH:8]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 10796Cesium carbonateHCID 87541309HCID 87541309, compound

Product 1

HCID 68693637HCID 68693637, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of the oxime from Step 4 (1.4 g, 3.3 mmol) and cesium carbonate (2.1 g, 6.7 mmol) in DMF (20 mL) was stirred at 80° C. for 18 h. The reaction was diluted with ethyl acetate and washed with water. The crude product was purified by chromatography on silica gel to give the title product.

Workup

  1. washwashed with water
  2. customThe crude product was purified by chromatography on silica gel

Sources & evidence

ORD record
ord-b9ed6023c6ea4a2e97b6afa22a2eb5fd
Source dataset
uspto-grants-2010_11
Patent number
US07834036B2

Reaction notes

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