Phthalimide → N-(3-nitrophenethyl)phthalimide

HRID 1173124노트

반응식

HRID 1173124 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[CH2:7][CH2:8]O)([O-:3])=[O:2].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[C:32]1(=[O:42])[NH:36][C:35](=[O:37])[C:34]2=[CH:38][CH:39]=[CH:40][CH:41]=[C:33]12.CCOC(/N=N/C(OCC)=O)=O>O1CCCC1>[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[CH2:7][CH2:8][N:36]1[C:35](=[O:37])[C:34]2=[CH:38][CH:39]=[CH:40][CH:41]=[C:33]2[C:32]1=[O:42])([O-:3])=[O:2]

참가 물질

6

반응물 4

HCID 6809PhthalimideHCID 11776TriphenylphosphineHCID 1040583-Nitrophenylethyl alcoholHCID 5462977Diethyl azodicarboxylate

생성물 1

HCID 22674056N-(3-nitrophenethyl)phthalimide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

3-Nitrophenethyl alcohol (15 g) was dissolved in tetrahydrofuran (225 ml). After adding triphenylphosphine (26 g) and phthalimide (13.9 g) thereto, the mixture was ice-cooled and diethylazodicarboxylate (15.5 ml) was added dropwise thereinto. After stirring at room temperature for one hour, the resulting crystals were collected by filtration, washed with diethyl ether and dried, to give N-(3-nitrophenethyl)phthalimide as colorless crystals.

후처리

  1. temperaturecooled
  2. filtrationthe resulting crystals were collected by filtration
  3. washwashed with diethyl ether
  4. customdried

출처 및 근거

ORD 기록
ord-100aa8ce8aa247fab77e2d43f5abcc9e
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07834049B2

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