反应详情

N-Acetyl-N-(3-nitrophenethyl)amine (2.1 g, Production Example 28b) was dissolved in ethanol (40 ml). To the mixture were added an iron powder (2.25 g), ammonium acetate (4.3 g) and water (20 ml), followed by heating under reflux for 1.5 hours. Solid was filtered off and washed with ethanol, and then the filtrate was partially evaporated. The residue was extracted with ethyl acetate, washed with brine and dried over anhydrous magnesium sulfate. The solvent was evaporated, to give the title compound (1.723 g, 96%) as a yellow oil.

1. temperatureby heating
2. temperatureunder reflux for 1.5 hours
3. filtrationSolid was filtered off
4. washwashed with ethanol
5. customthe filtrate was partially evaporated
6. extractionThe residue was extracted with ethyl acetate
7. washwashed with brine
8. dry with materialdried over anhydrous magnesium sulfate
9. customThe solvent was evaporated