Hydrochloric Acid → HCID 14610428, compound

HRID 1173131Notes

Reaction equation

HRID 1173131 reaction equation
C(OC([NH:8][CH2:9][CH2:10][C:11]1[CH:12]=[C:13]([NH:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH:14]=[CH:15][CH:16]=1)=O)(C)(C)C.[ClH:23]>C(O)C>[ClH:23].[CH2:21]([O:20][C:18]([NH:17][C:13]1[CH:12]=[C:11]([CH:16]=[CH:15][CH:14]=1)[CH2:10][CH2:9][NH2:8])=[O:19])[CH3:22]

Participants

4

Reactant 2

HCID 313Hydrochloric Acid3×HCID 22674139HCID 22674139, compound

Product 1

HCID 14610428HCID 14610428, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent3×

Procedure

3-(2-t-Butoxycarbonylaminoethyl)-ethoxycarbonylaminobenzene (14.96 g, Production Example 36b) was dissolved in ethanol (15 ml), to which was then added hydrochloric acid (15 ml) under ice-cooling, followed by stirring at room temperature for 20 minutes. Hydrochloric acid (12 ml) and ethanol (15 ml) were added thereto, followed by stirring at room temperature for 20 minutes. Then, hydrochloric acid (20 ml) and ethanol (30 ml) were further added thereto, followed by stirring at room temperature for 30 minutes. After evaporating (subjecting azeotropic distillation together with toluene) the solvent, the title compound (11.99 g) was obtained as pale yellow crystals.

Workup

  1. stirringby stirring at room temperature for 20 minutes
  2. stirringby stirring at room temperature for 30 minutes
  3. customAfter evaporating (
  4. distillationdistillation together with toluene) the solvent

Sources & evidence

ORD record
ord-b6d0d945daa644d79234b8f4320132ed
Source dataset
uspto-grants-2010_11
Patent number
US07834049B2

Reaction notes

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