4-Hydroxybenzaldehyde → 4-[(Cyclopropylmethyl)(3-{[4-(hydroxymethyl)phenyl]oxy}propyl)amino]-2-(trifluoromethyl)benzonitrile

HRID 1173396Notes

Reaction equation

HRID 1173396 reaction equation
[CH:1]1([CH2:4][N:5]([CH2:18][CH2:19][CH2:20][OH:21])[C:6]2[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[C:8]([C:14]([F:17])([F:16])[F:15])[CH:7]=2)[CH2:3][CH2:2]1.O[C:23]1[CH:30]=[CH:29][C:26]([CH:27]=[O:28])=[CH:25][CH:24]=1>>[CH:1]1([CH2:4][N:5]([CH2:18][CH2:19][CH2:20][O:21][C:23]2[CH:30]=[CH:29][C:26]([CH2:27][OH:28])=[CH:25][CH:24]=2)[C:6]2[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[C:8]([C:14]([F:16])([F:17])[F:15])[CH:7]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 1264-HydroxybenzaldehydeHCID 114607194-[(Cyclopropylmethyl)(3-hydroxypropyl)amino]-2-(trifluoromethyl)benzonitrile

Product 1

HCID 116111184-[(Cyclopropylmethyl)(3-{[4-(hydroxymethyl)phenyl]oxy}propyl)amino]-2-(trifluoromethyl)benzonitrile

Procedure

Synthesized as described in Example 5B from 4-[(cyclopropylmethyl)(3-hydroxypropyl)amino]-2-(trifluoromethyl)benzonitrile and 4-hydroxybenzaldehyde: MS (APCI) m/z 405 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-f4b566d2d3bd4c3dad41b545759e814f
Source dataset
uspto-grants-2010_11
Patent number
US07834063B2

Reaction notes

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