Trifluoroacetic acid → HCID 68635447, compound

HRID 1173489Notes

Reaction equation

HRID 1173489 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH2:10][CH2:11][NH:12][C:13]2[CH:20]=[CH:19][C:16]([C:17]#[N:18])=[C:15]([C:21]([F:24])([F:23])[F:22])[CH:14]=2)=[CH:5][CH:4]=1.[C:25]([OH:31])([C:27](F)(F)F)=[O:26]>>[C:17]([C:16]1[CH:19]=[CH:20][C:13]([N:12]([CH2:11][CH2:10][O:9][C:6]2[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[CH2:27][C:25]([O:31][C:15]([CH3:21])([CH3:16])[CH3:14])=[O:26])=[CH:14][C:15]=1[C:21]([F:22])([F:23])[F:24])#[N:18]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 56557142HCID 56557142, compound

Product 1

HCID 68635447HCID 68635447, compound

Procedure

Synthesized as described in Example 70B from 4-[(2-{[4-(methyloxy)phenyl]oxy}ethyl)amino]-2-(trifluoromethyl)benzonitrile, excluding TFA deprotection of tert-butyl ester. Purified by flash chromatography (EtOAc/hexanes), obtained as a colorless gum: MS (APCI) m/z 451 (M+1).

Workup

  1. customSynthesized
  2. customPurified by flash chromatography (EtOAc/hexanes)
  3. customobtained as a colorless gum

Sources & evidence

ORD record
ord-c38afce03ca14654a6fe0e45207f885a
Source dataset
uspto-grants-2010_11
Patent number
US07834063B2

Reaction notes

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