反应详情

温度

80 °C

The compound (552.4 mg) obtained in Example 127-8 was dissolved in DMF (1.67 ml) and added with zinc cyanide (94.3 mg) and tetrakistriphenyl phosphine palladium (61.8 mg), followed by stirring at 80° C. for 48 hours. The reaction solution was added with chloroform and washed with a 7% aqueous ammonium solution and saturated saline solution. The solution was dried with anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified through silica gel column chromatography (chloroform/methanol), thereby obtaining the subject compound (436.8 mg) as a yellow oily substance.

1. washwashed with a 7% aqueous ammonium solution and saturated saline solution
2. dry with materialThe solution was dried with anhydrous sodium sulfate
3. concentrationconcentrated under reduced pressure
4. customThe residue was purified through silica gel column chromatography (chloroform/methanol)