反应详情

The compound (436.8 mg) obtained in Example 127-9 was dissolved in THF (21.8 ml) and added with lithium aluminum hydride (138.7 mg), followed by stirring at room temperature for 24 hours. The reaction solution was added with ethyl acetate, methanol, and a 10% aqueous potassium sodium tartrate solution, and stirred for 1 hour, followed by separation/extraction with chloroform. The extract was washed with saturated saline solution and dried with anhydrous sodium sulfate, followed by concentration under reduced pressure. The residue was purified through silica gel column chromatography (chloroform/ethyl acetate), thereby obtaining the subject compound (189.7 mg) as a yellow oily substance.

1. extractionfollowed by separation/extraction with chloroform
2. washThe extract was washed with saturated saline solution
3. dry with materialdried with anhydrous sodium sulfate
4. concentrationfollowed by concentration under reduced pressure
5. customThe residue was purified through silica gel column chromatography (chloroform/ethyl acetate)