反应详情

温度

60 °C

A solution containing the product from Example 8A (16.97 g, 30.6 mmol) in THF (150 mL) was treated with HCl solution (50 mL, 4 N in dioxane), stirred at 60° C. for 2 hours, cooled and adjusted to pH 8 with 10% NaOH solution. The reaction mixture was partitioned between ethyl acetate and water, and the organic phase was washed with brine and concentrated to give the title compound (13.74 g).

1. temperaturecooled
2. customThe reaction mixture was partitioned between ethyl acetate and water
3. washthe organic phase was washed with brine
4. concentrationconcentrated