Hydrochloric Acid → HCID 86726216, compound

HRID 1174280Notes

Reaction equation

HRID 1174280 reaction equation
[OH:1][C@@H:2]([CH2:28][C@@H:29]([NH:37][C:38](=[O:49])[C@@H:39]([NH:44][C:45]([O:47][CH3:48])=[O:46])[C:40]([CH3:43])([CH3:42])[CH3:41])[CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)[C@@H:3]([NH:17]C(=O)OCC1C=CC=CC=1)[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)=[CH:7][CH:6]=1.Cl>CO.[OH-].[OH-].[Pd+2]>[NH2:17][C@@H:3]([CH2:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)=[CH:9][CH:10]=1)[C@@H:2]([OH:1])[CH2:28][C@@H:29]([NH:37][C:38]([C@@H:39]([NH:44][C:45](=[O:46])[O:47][CH3:48])[C:40]([CH3:42])([CH3:43])[CH3:41])=[O:49])[CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86726217HCID 86726217, compound

Product 1

HCID 86726216HCID 86726216, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Conditions

Temperature
25 °C

Procedure

A solution containing the product from Example 104A (0.045 mmol) in methanol (0.5 mL) was treated with Pd(OH)2 on carbon (0.010 g, 20% Pd by wt.) and HCl solution (0.035 mL, 4N in dioxane), stirred under a hydrogen atmosphere (balloon pressure) for 4 hours at 25° C., filtered through a bed of celite®, rinsed with methanol, and concentrated to give the title compound as the hydrochloride salt, which was used without further purification.

Workup

  1. filtrationfiltered through a bed of celite®
  2. washrinsed with methanol
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-2c1bd1e0891448a68d150b8ec5432480
Source dataset
uspto-grants-2010_11
Patent number
US07834043B2

Reaction notes

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