Hydrochloric Acid → HCID 61818371, compound

HRID 1174291Notes

Reaction equation

HRID 1174291 reaction equation
[CH3:1][C@@H:2]([CH2:20][CH3:21])[C@H:3]([NH:8][C:9]([N:11]([CH3:19])[CH2:12][C:13]1[N:14]=[C:15]([CH3:18])[S:16][CH:17]=1)=[O:10])[C:4]([O:6]C)=[O:5].[OH-].[Li+].Cl>O1CCOCC1>[CH3:1][C@@H:2]([CH2:20][CH3:21])[C@H:3]([NH:8][C:9]([N:11]([CH3:19])[CH2:12][C:13]1[N:14]=[C:15]([CH3:18])[S:16][CH:17]=1)=[O:10])[C:4]([OH:6])=[O:5]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 67406590HCID 67406590, compound

Product 1

HCID 61818371HCID 61818371, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
25 °C

Procedure

A solution of the product from Example 109D (0.38 g, 1.2 mmol) in dioxane (5 mL) was treated with an aqueous solution of lithium hydroxide (5.0 mL, 0.5 M), stirred for 0.5 hours at 25° C., treated with aqueous HCl (2.5 mL, 1 N), and partitioned between ethyl acetate and water. The organic phase was washed with brine and dried over Na2SO4, filtered and concentrated to give the title compound.

Workup

  1. custompartitioned between ethyl acetate and water
  2. washThe organic phase was washed with brine
  3. dry with materialdried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-85cd6855e51a4ce69316211b9fa3cf17
Source dataset
uspto-grants-2010_11
Patent number
US07834043B2

Reaction notes

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