HRID1174311

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：COc1cccc(-c2ccc(C[C@@H](C[C@H](O)[C@H](Cc3ccccc3)NCOC(C)(C)C)NC(=O)OCc3ccccc3)cc2)n1

HCID86726223

未命名化合物

PRODUCTS

生成物

结构：COc1cccc(-c2ccc(C[C@@H](C[C@H](O)[C@@H](N)Cc3ccccc3)NC(=O)OCc3ccccc3)cc2)n1

HCID86726224

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

CONDITIONS

反应条件

温度: 25 °C

PROCEDURE

实验过程

A solution of the product from Example 113C (0.093 g, 0.15 mmol) in THF (1 mL) was treated with an HCl solution (0.26 mL, 4 N in dioxane), stirred at 25° C. for 64 hours, and concentrated. The concentrate was treated with ethanol and concentrated several times to give the title compound as the hydrochloride salt.

WORKUP

后处理

concentrationconcentrated
additionThe concentrate was treated with ethanol
concentrationconcentrated several times

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-096abca135234951995f4a1b724dc4a6
来源数据集: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07834043B2
来源说明: uspto-grants-2010_11

反应 SMILES

C(OC[NH:7][C@@H:8]([CH2:39][C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1)[C@@H:9]([OH:38])[CH2:10][C@@H:11]([NH:27][C:28](=[O:37])[O:29][CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)[CH2:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH3:26])[N:20]=2)=[CH:15][CH:14]=1)(C)(C)C.Cl>C1COCC1>[NH2:7][C@@H:8]([CH2:39][C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1)[C@@H:9]([OH:38])[CH2:10][C@@H:11]([NH:27][C:28](=[O:37])[O:29][CH2:30][C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1)[CH2:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH3:26])[N:20]=2)=[CH:15][CH:14]=1