反应详情

温度

25 °C

A solution containing the product from Example 1C (0.088 g, 0.15 mmol) in a mixture of THF (2 mL) and aqueous HCl (0.26 mL, 4 N) was stirred at 25° C. for 16 hours, then heated at 60° C. for 2 hours, cooled and concentrated. The residue was treated with ethanol and concentrated several times to give the title compound as the hydrochloride salt, which was used without further purification.

1. temperatureheated at 60° C. for 2 hours
2. temperaturecooled
3. concentrationconcentrated
4. additionThe residue was treated with ethanol
5. concentrationconcentrated several times