Hydrochloric Acid → HCID 67407130, compound

HRID 1174338Notes

Reaction equation

[CH3:1][C:2]([CH3:63])([CH3:62])[C@H:3]([N:48]1[CH2:52][CH2:51][N:50]([CH2:53][C:54]2[CH:59]=[CH:58][CH:57]=[C:56]([CH3:60])[N:55]=2)[C:49]1=[O:61])[C:4]([NH:6][C@@H:7]([CH2:41][C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1)[C@@H:8]([OH:40])[CH2:9][C@@H:10]([NH:24][C:25]([C@@H:27]([NH:32]C(=O)OC(C)(C)C)[C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[CH2:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=2)=[CH:14][CH:13]=1)=[O:5].Cl>C1COCC1>[NH2:32][C@@H:27]([C:28]([CH3:31])([CH3:30])[CH3:29])[C:25]([NH:24][C@@H:10]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=2)=[CH:14][CH:13]=1)[CH2:9][C@H:8]([OH:40])[C@@H:7]([NH:6][C:4](=[O:5])[C@@H:3]([N:48]1[CH2:52][CH2:51][N:50]([CH2:53][C:54]2[CH:59]=[CH:58][CH:57]=[C:56]([CH3:60])[N:55]=2)[C:49]1=[O:61])[C:2]([CH3:1])([CH3:63])[CH3:62])[CH2:41][C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1)=[O:26]

Participants

Conditions

Temperature: 25 °C

Procedure

A solution containing the product from Example 130D (0.024 g, 0.028 mmol) in a mixture of THF (1 mL) and aqueous HCl (0.050 mL, 4 N) was stirred at 25° C. for 16 hours, and concentrated under reduced pressure. The residue was treated with ethanol and concentrated several times to give the title compound as the hydrochloride salt, which was used without further purification.

Workup

concentrationconcentrated under reduced pressure
additionThe residue was treated with ethanol
concentrationconcentrated several times

Sources & evidence

ORD record: ord-14fc506ef26a44918be17b6e68b7256f
Source dataset: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07834043B2

Reaction notes

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