Trifluoroacetic acid → HCID 42625472, compound

HRID 1174346Notes

Reaction equation

HRID 1174346 reaction equation
[F:1][C:2]1[CH:26]=[CH:25][CH:24]=[CH:23][C:3]=1[CH2:4][N:5]1[CH2:9][CH2:8][N:7]([C@@H:10]([C:18]([CH3:21])([CH3:20])[CH3:19])[C:11]([O:13]C(C)(C)C)=[O:12])[C:6]1=[O:22].FC(F)(F)C(O)=O>ClCCl>[F:1][C:2]1[CH:26]=[CH:25][CH:24]=[CH:23][C:3]=1[CH2:4][N:5]1[CH2:9][CH2:8][N:7]([C@@H:10]([C:18]([CH3:20])([CH3:21])[CH3:19])[C:11]([OH:13])=[O:12])[C:6]1=[O:22]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67407531HCID 67407531, compound

Product 1

HCID 42625472HCID 42625472, compoundYield 73%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of Example 135B (199 mg, 0.54 mmol) in dichloromethane (1.5 mL) was treated with trifluoroacetic acid (1.5 mL) at 25° C. for 16 h. The solvents were evaporated, and the crude residue was purified using reverse phase chromatography using 95% water (0.1% trifluoroacetic acid)/5% acetonitrile-100% acetonitrile to give the title compound (0.121 g, 73%).

Workup

  1. customThe solvents were evaporated
  2. customthe crude residue was purified

Sources & evidence

ORD record
ord-66c46d716c2548b3a8950edd5202fb27
Source dataset
uspto-grants-2010_11
Patent number
US07834043B2

Reaction notes

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