Trifluoroacetic acid → HCID 67407515, compound

HRID 1174359Notes

Reaction equation

HRID 1174359 reaction equation
[OH:1][C:2]1[CH:26]=[CH:25][CH:24]=[CH:23][C:3]=1[CH2:4][N:5]1[CH2:9][CH2:8][N:7]([C@@H:10]([C:18]([CH3:21])([CH3:20])[CH3:19])[C:11]([O:13]C(C)(C)C)=[O:12])[C:6]1=[O:22].FC(F)(F)C(O)=O>ClCCl>[OH:1][C:2]1[CH:26]=[CH:25][CH:24]=[CH:23][C:3]=1[CH2:4][N:5]1[CH2:9][CH2:8][N:7]([C@@H:10]([C:18]([CH3:20])([CH3:21])[CH3:19])[C:11]([OH:13])=[O:12])[C:6]1=[O:22]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67406816HCID 67406816, compound

Product 1

HCID 67407515HCID 67407515, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of Example 145B (0.127 g, 0.35 mmol) in dichloromethane (1.75 mL) was treated with trifluoroacetic acid (1.75 mL) at 25° C. for 16 h. The solvents were evaporated, and the crude residue was azeotroped twice with ethyl acetate to give crude material which was used directly in the next step.

Workup

  1. customThe solvents were evaporated
  2. customthe crude residue was azeotroped twice with ethyl acetate
  3. customto give crude material which

Sources & evidence

ORD record
ord-61ec6278cc8740d7b92afaff37dbd106
Source dataset
uspto-grants-2010_11
Patent number
US07834043B2

Reaction notes

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