Piperidine → HCID 131728538, compound

HRID 1174391Notes

Reaction equation

HRID 1174391 reaction equation
[CH2:1]([C@H:8]([NH:39][C:40](=[O:83])[C@H:41]([CH2:60][C:61]([NH:63][C:64]([C:77]1[CH:82]=[CH:81][CH:80]=[CH:79][CH:78]=1)([C:71]1[CH:76]=[CH:75][CH:74]=[CH:73][CH:72]=1)[C:65]1[CH:70]=[CH:69][CH:68]=[CH:67][CH:66]=1)=[O:62])[NH:42]C(OCC1C2C=CC=CC=2C2C1=CC=CC=2)=O)[C@@H:9]([OH:38])[CH2:10][C@@H:11]([NH:25][C:26](=[O:37])[C@H:27]([C:33]([CH3:36])([CH3:35])[CH3:34])[NH:28][C:29]([O:31][CH3:32])=[O:30])[CH2:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)=[CH:15][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.N1CCCCC1>CN(C)C=O>[CH2:1]([C@H:8]([NH:39][C:40](=[O:83])[C@H:41]([CH2:60][C:61]([NH:63][C:64]([C:71]1[CH:72]=[CH:73][CH:74]=[CH:75][CH:76]=1)([C:65]1[CH:70]=[CH:69][CH:68]=[CH:67][CH:66]=1)[C:77]1[CH:78]=[CH:79][CH:80]=[CH:81][CH:82]=1)=[O:62])[NH2:42])[C@@H:9]([OH:38])[CH2:10][C@@H:11]([NH:25][C:26](=[O:37])[C@H:27]([C:33]([CH3:34])([CH3:35])[CH3:36])[NH:28][C:29]([O:31][CH3:32])=[O:30])[CH2:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)=[CH:15][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 8082PiperidineHCID 131728539HCID 131728539, compound

Product 1

HCID 131728538HCID 131728538, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of Example 168A (45 mg, 0.04 mmol) in N,N-dimethylformamide (0.4 mL) was treated with piperidine (80 μL) at 25° C. for 16 h. The solvents were evaporated to give the crude title compound which was used directly in the next step.

Workup

  1. customThe solvents were evaporated

Sources & evidence

ORD record
ord-e34d5701d9e04941bd627f7e8806a8b8
Source dataset
uspto-grants-2010_11
Patent number
US07834043B2

Reaction notes

Loading…