Potassium Carbonate → 5-Methyl-1-(propan-2-yl)pyrazolidin-3-one

HRID 1174490Notes

Reaction equation

HRID 1174490 reaction equation
Cl.[CH3:2][CH:3]([N:5]1[CH:9]([CH3:10])[CH2:8][C:7](=[O:11])[NH:6]1)[CH3:4].C(=O)([O-])[O-].[K+].[K+]>C(OCC)(=O)C>[CH3:2][CH:3]([N:5]1[CH:9]([CH3:10])[CH2:8][C:7](=[O:11])[NH:6]1)[CH3:4]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 68768722HCID 68768722, compound

Product 1

HCID 576420605-Methyl-1-(propan-2-yl)pyrazolidin-3-one

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

(1-Methylethyl)-5-methyl-3-pyrazolidinone monohydrochloride (150 g; 0.84 mol) is treated with saturated aqueous potassium carbonate (1.2 L) and ethyl acetate (1.0 L). The mixture is filtered and the phases are separated. The organic phase is dried with anhydrous sodium sulphate, filtered and evaporated in vacuo to yield 1-(1-methylethyl)-5-methyl-3-pyrazolidinone as a solid.

Workup

  1. filtrationThe mixture is filtered
  2. customthe phases are separated
  3. dry with materialThe organic phase is dried with anhydrous sodium sulphate
  4. filtrationfiltered
  5. customevaporated in vacuo

Sources & evidence

ORD record
ord-e30a7168d66b42998e45c77042827be4
Source dataset
uspto-grants-2010_11
Patent number
US07838500B2

Reaction notes

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