Hydrochloric Acid → 8-(cis-Hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-3-methyl-7-(3-methyl-but-2-enyl)-1-(2-oxo-2-phenyl-ethyl)-3,7-dihydro-purine-2,6-dione hydrochloride

HRID 1174575Notes

Reaction equation

HRID 1174575 reaction equation
[CH3:1][N:2]1[C:10]2[N:9]=[C:8]([N:11]3[CH2:15][CH:14]4[CH2:16][N:17](C(OC(C)(C)C)=O)[CH2:18][CH:13]4[CH2:12]3)[N:7]([CH2:26][CH:27]=[C:28]([CH3:30])[CH3:29])[C:6]=2[C:5](=[O:31])[N:4]([CH2:32][C:33](=[O:40])[C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[C:3]1=[O:41].[ClH:42]>C(OCC)(=O)C>[ClH:42].[CH2:12]1[C@@H:13]2[CH2:18][NH:17][CH2:16][C@@H:14]2[CH2:15][N:11]1[C:8]1[N:7]([CH2:26][CH:27]=[C:28]([CH3:30])[CH3:29])[C:6]2[C:5](=[O:31])[N:4]([CH2:32][C:33](=[O:40])[C:34]3[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=3)[C:3](=[O:41])[N:2]([CH3:1])[C:10]=2[N:9]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68688281HCID 68688281, compound

Product 1

HCID 686902268-(cis-Hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-3-methyl-7-(3-methyl-but-2-enyl)-1-(2-oxo-2-phenyl-ethyl)-3,7-dihydro-purine-2,6-dione hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

This compound was obtained by dissolving 50 mg of tert-butyl 5-[3-methyl-7-(3-methyl-but-2-enyl)-2,6-dioxo-1-(2-oxo-2-phenyl-ethyl)-2,3,6,7-tetrahydro-1H-purin-8-yl]-hexahydropyrrolo[3,4-c]pyrrole-2-carboxylate in 5 ml of ethyl acetate, treating the solution with excess hydrogen chloride solution in ethyl acetate, concentrating in a rotary evaporator and stirring with diisopropyl ether.

Workup

  1. customThis compound was obtained
  2. concentrationconcentrating in a rotary evaporator

Sources & evidence

ORD record
ord-7797eacd64cc4012a37a96d6fb4672e6
Source dataset
uspto-grants-2010_11
Patent number
US07838528B2

Reaction notes

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