反应详情

4-Butoxybenzoic acid was reacted with 4-(1,4-dioxa-7-azaspiro[4,4]non-7-yl)phenylamine by method E. The resulting amide (0.25 g) in acetone (10 ml) was mixed with para-toluenesulfonic acid (monohydrate, 109 mg), and the mixture was refluxed for 8 hours. After addition of triethylamine (0.5 ml), the mixture was diluted with water and extracted with ethyl acetate. The organic phase was dried over magnesium sulfate and concentrated. The product with the molecular weight of 352.44 (C21H24N2O3); MS (ESI): 353 (M+H+) was obtained in this way.

1. temperaturethe mixture was refluxed for 8 hours
2. extractionextracted with ethyl acetate
3. dry with materialThe organic phase was dried over magnesium sulfate
4. concentrationconcentrated
5. customMS (ESI): 353 (M+H+) was obtained in this way