Ethylparaben → HCID 25019181, compound

HRID 1174714Notes

Reaction equation

HRID 1174714 reaction equation
C([O:3][C:4](=[O:12])[C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1)C.[CH:13]1(Br)[CH2:16][CH2:15][CH2:14]1.[C:18]([O-])([O-])=O.[Cs+].[Cs+].[OH-].[Na+]>C(O)C.CN(C=O)C>[CH:13]1([CH2:18][O:11][C:8]2[CH:7]=[CH:6][C:5]([C:4]([OH:3])=[O:12])=[CH:10][CH:9]=2)[CH2:16][CH2:15][CH2:14]1

Participants

7

Reactant 4

HCID 8434EthylparabenHCID 10796Cesium carbonateHCID 14798Sodium HydroxideHCID 78110Bromocyclobutane

Product 1

HCID 25019181HCID 25019181, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 6228DimethylformamideSolvent

Procedure

4-Hydroxybenzoic acid ethyl ester was alkylated with cyclobutyl bromide by standard methods (DMF, Cs2CO3), and the resulting ester was hydrolyzed by boiling with sodium hydroxide in aqueous ethanol. The product with the molecular weight of 206.24 (C12H14O3); MS (ESI): 207 (M+H+) was obtained in this way.

Workup

  1. customMS (ESI): 207 (M+H+) was obtained in this way

Sources & evidence

ORD record
ord-02c353e06a534a01bb961b082f231ec6
Source dataset
uspto-grants-2010_11
Patent number
US07838547B2

Reaction notes

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