HCID 57771688, compound → HCID 57771791, compound

HRID 1174955Notes

Reaction equation

HRID 1174955 reaction equation
[CH3:1][N:2]([C:10]1[O:11][C:12]2[CH:18]=[CH:17][C:16]([N+:19]([O-])=O)=[CH:15][C:13]=2[N:14]=1)[CH2:3][CH2:4][N:5]1[CH2:9][CH2:8][CH2:7][CH2:6]1>[Fe].C(O)(=O)C>[CH3:1][N:2]([CH2:3][CH2:4][N:5]1[CH2:9][CH2:8][CH2:7][CH2:6]1)[C:10]1[O:11][C:12]2[CH:18]=[CH:17][C:16]([NH2:19])=[CH:15][C:13]=2[N:14]=1

Participants

4

Reactant 1

HCID 57771688HCID 57771688, compound

Product 1

HCID 57771791HCID 57771791, compound

Reagents, catalysts & solvents 2

HCID 23925IronCatalystHCID 176Acetic AcidSolvent

Procedure

The title compound is prepared according to the procedure outlined in Example 61, Step 3 using methyl(5-nitro-benzooxazol-2-yl)-(2-pyrrolidin-1-yl-ethyl)-amine (160 mg, 0.55 mmol), iron powder (154 mg, 2.75 mmol), and acetic acid (5 mL) to yield 60 mg (42%) of product: mass spectrum (ion-spray): (m/z)=261.2 (M+1).

Sources & evidence

ORD record
ord-88178dd9240a42f8bad24e7ceba225a5
Source dataset
uspto-grants-2010_11
Patent number
US07838543B2

Reaction notes

Loading…