Lithium Hydroxide → HCID 61261489, compound

HRID 1175117Notes

Reaction equation

HRID 1175117 reaction equation
[CH3:1][C:2]([NH:8][C:9]([C:11]1[CH:16]=[N:15][CH:14]=[CH:13][N:12]=1)=[O:10])([CH3:7])[C:3]([O:5]C)=[O:4].[Li+].[OH-]>CO.O.CCOC(C)=O>[CH3:7][C:2]([NH:8][C:9]([C:11]1[CH:16]=[N:15][CH:14]=[CH:13][N:12]=1)=[O:10])([CH3:1])[C:3]([OH:5])=[O:4]

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 68732840HCID 68732840, compound

Product 1

HCID 61261489HCID 61261489, compoundYield 88%

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 22242641Methanol--water (1/1)Solvent

Conditions

Temperature
22 °C

Procedure

A solution of methyl 2-methyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoate (0.36, 1.6 mmol) in MeOH/H2O (2:1) (6.0 mL) was treated with LiOH (0.08 g, 3.2 mmol) and stirred at 22° C. After 12 h, the reaction was diluted with 1-O and EtOAc and the layers were separated. The aqueous layer was acidified with 1 M HCl in water (28 mL) to an approximate pH˜2. The aqueous was extracted with EtOAc (3×). These three combined extracts were dried (Na2SO4), filtered and concentrated to obtain the title compound (0.286 g, 88%).

Workup

  1. customthe layers were separated
  2. extractionThe aqueous was extracted with EtOAc (3×)
  3. dry with materialThese three combined extracts were dried (Na2SO4)
  4. filtrationfiltered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-bcecc208e9464b998541654d08037acc
Source dataset
uspto-grants-2010_11
Patent number
US07838673B2

Reaction notes

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