Sodium Bicarbonate → HCID 59558387, compound

HRID 1175177Notes

Reaction equation

HRID 1175177 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:14]2[N:23]=[CH:22][C:21]3[CH2:20][CH2:19][CH:18]=[C:17]([O:24]CC)[C:16]=3[N:15]=2)[CH:5]=[CH:6][C:7]=1[N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1.C([O-])(O)=O.[Na+]>C(O)(=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([C:14]2[N:23]=[CH:22][C:21]3[CH2:20][CH2:19][CH2:18][C:17](=[O:24])[C:16]=3[N:15]=2)[CH:5]=[CH:6][C:7]=1[N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 59558610HCID 59558610, compound

Product 1

HCID 59558387HCID 59558387, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

2-(3-Chloro-4-morpholin-4-yl-phenyl)-8-ethoxy-5,6-dihydro-quinazoline (0.38 g, 1.0 mmol) is refluxed in 20 ml 25% aqueous acetic acid for 1 hour. The reaction mixture is neutralized using solid NaHCO3 and the product is extracted with ethyl acetate. MS (m/z, ES+): 344 (MH+).

Workup

  1. extractionthe product is extracted with ethyl acetate

Sources & evidence

ORD record
ord-4d4496dd84ff42f6bfcaa410d51ee928
Source dataset
uspto-grants-2010_11
Patent number
US07838674B2

Reaction notes

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