HCID 11528520, compound → HCID 11586451, compound

HRID 1175187Notes

Reaction equation

HRID 1175187 reaction equation
[CH3:1][O:2][C:3]([N:5]1[CH2:10][CH:9]=[CH:8][C@H:7]2[O:11][C:12]([NH2:14])=[N:13][C@@H:6]12)=[O:4]>CN(C=O)C>[CH3:1][O:2][C:3]([N:5]1[CH2:10][CH:9]=[CH:8][C@H:7]2[NH:14][C:12](=[O:11])[NH:13][C@@H:6]12)=[O:4]

Participants

3

Reactant 1

HCID 11528520HCID 11528520, compound

Product 1

HCID 11586451HCID 11586451, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 5 (200 mg, 1 mmol) in DMF (10 ml) is brought to reflux for 1 h. After evaporating the solvent, the crude product (280 mg) is purified by chromatography on silica gel (Et2O/MeOH, 93:7). Product 19 (Rf=0.36, Et2O/MeOH, 92:8) is obtained in the form of a yellow solid (81 mg, 40%).

Workup

  1. temperatureto reflux for 1 h
  2. customAfter evaporating the solvent
  3. customthe crude product (280 mg) is purified by chromatography on silica gel (Et2O/MeOH, 93:7)

Sources & evidence

ORD record
ord-5a66f3cd73d24c3b9aea0960a9efe211
Source dataset
uspto-grants-2010_11
Patent number
US07838681B2

Reaction notes

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