Methanol → HCID 68689367, compound

HRID 1175218Notes

Reaction equation

HRID 1175218 reaction equation
[CH2:1]([O:8][C@@H:9]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([C:18]([O:20]CC3C=CC=CC=3)=[O:19])[CH:16]=2)[CH2:11][CH2:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+].CO>C1COCC1>[CH2:1]([O:8][C@@H:9]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([C:18]([OH:20])=[O:19])[CH:16]=2)[CH2:11][CH2:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 90254651HCID 90254651, compound

Product 1

HCID 68689367HCID 68689367, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of the title compound of Step 3 (62.7 mg, 0.175) in 1.00 ml of THF was added 1.00 ml of 6 N NaOH and 1.00 ml MeOH. The resulting mixture was stirred overnight. The mixture was acidified to neutral pH, concentrated and the title compound was purified on a Biotage MPLC.

Workup

  1. concentrationconcentrated
  2. customthe title compound was purified on a Biotage MPLC

Sources & evidence

ORD record
ord-a8185ddd0b8d4ca6984ab32d5cdd4f4f
Source dataset
uspto-grants-2010_11
Patent number
US07838676B2

Reaction notes

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