Sodium hydride → HCID 53628354, compound

HRID 1175392Notes

Reaction equation

HRID 1175392 reaction equation
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([S:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([F:17])[C:12]=2[F:18])[N:3]=1.[CH3:19][C:20]([Si:23]([CH3:33])([CH3:32])[O:24][CH2:25][C@H:26]([OH:31])[CH2:27][O:28][CH2:29][CH3:30])([CH3:22])[CH3:21].[H-].[Na+]>C1COCC1>[Cl:8][C:6]1[CH:7]=[C:2]([O:31][C@H:26]([CH2:27][O:28][CH2:29][CH3:30])[CH2:25][O:24][Si:23]([C:20]([CH3:19])([CH3:21])[CH3:22])([CH3:32])[CH3:33])[N:3]=[C:4]([S:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([F:17])[C:12]=2[F:18])[N:5]=1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 859280374,6-Dichloro-2-((2,3-difluorobenzyl)thio)pyrimidineHCID 86619876HCID 86619876, compound2×

Product 1

HCID 53628354HCID 53628354, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The subtitle compound was prepared according to the procedure outlined in example 1 step iv) using 4,6-Dichloro-2-[(2,3-difluorobenzyl)thio]pyrimidine (product of example 1 step ii) (0.43 g), (2R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-ethoxy-2-propanol (product of step iii) (0.47 g), THF (20 mL) and 60% sodium hydride (67 mg), to give the subtitle compound as a colourless oil. Yield: 0.7 g

Workup

  1. customThe subtitle compound was prepared

Sources & evidence

ORD record
ord-68e5856330ae4e1cb0f6266340f81c5a
Source dataset
uspto-grants-2010_11
Patent number
US07838675B2

Reaction notes

Loading…