Lithium Bromide → HCID 11370398, compound

HRID 1175661Notes

Reaction equation

HRID 1175661 reaction equation
CS([CH2:5][C:6]1[CH:22]=[CH:21][C:9]([O:10][C:11]2[CH:12]=[C:13]([C:19]#[N:20])[C:14](=[CH:17][CH:18]=2)[C:15]#[N:16])=[CH:8][CH:7]=1)(=O)=O.[Li+].[Br-:24]>C1COCC1>[Br:24][CH2:5][C:6]1[CH:22]=[CH:21][C:9]([O:10][C:11]2[CH:12]=[C:13]([C:19]#[N:20])[C:14](=[CH:17][CH:18]=2)[C:15]#[N:16])=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 82050Lithium BromideHCID 11449786HCID 11449786, compound

Product 1

HCID 11370398HCID 11370398, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 4-[4-(methansulfonylmethyl)phenoxy]phthalonitrile (1.2 g, 3.3 mmol) prepared according to Example 2, in anhydrous THF (15 ml) kept in an inert atmosphere, LiBr (0.4 g, 4.6 mmol) was added. The solution was refluxed for 1 hour, during which a white precipitate formed, then it was allowed to cool at room temperature. The white precipitate was filtered off and the solvent was evaporated. From the crude mixture the desired product was isolated by filtration on silica gel (eluent: chloroform). (1.0 g, 95%)

Workup

  1. additionwas added
  2. temperatureThe solution was refluxed for 1 hour, during which a white precipitate
  3. customformed
  4. filtrationThe white precipitate was filtered off
  5. customthe solvent was evaporated

Sources & evidence

ORD record
ord-200f7660630540b099aad5e907f362dd
Source dataset
uspto-grants-2010_11
Patent number
US07842682B2

Reaction notes

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