Pyridine → HCID 66745445, compound

HRID 1175747Notes

Reaction equation

HRID 1175747 reaction equation
Cl[C:2]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:3].[CH3:11][N:12]1[C:20]2[CH:19]=[CH:18][CH:17]=[C:16]([NH2:21])[C:15]=2[CH:14]=[N:13]1.N1C=CC=CC=1>C(Cl)(Cl)Cl.C1COCC1>[CH3:11][N:12]1[C:20]2[C:15](=[C:16]([NH:21][C:2](=[O:3])[O:4][C:5]3[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=3)[CH:17]=[CH:18][CH:19]=2)[CH:14]=[N:13]1

Participants

6

Reactant 3

HCID 1049PyridineHCID 15891Phenyl chloroformateHCID 1538381H-Indazol-4-amine, 1-methyl-

Product 1

HCID 66745445HCID 66745445, compound

Reagents, catalysts & solvents 2

HCID 6212ChloroformSolventHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
0 °C

Procedure

A solution of phenyl chloroformate (1.1 mmol) in chloroform was cooled to 0° C. 1-methyl-1H-indazole-4-amine in dry THF was added to the reaction mixture dropwise at 0° C. Pyridine (1 mmol) was added to the reaction mixture. Reaction mixture was stirred at 0° C. for 30 minutes and was then stirred at room temperature for 15 hours.

Workup

  1. customReaction mixture
  2. stirringwas then stirred at room temperature for 15 hours

Sources & evidence

ORD record
ord-bee261ee171c4786982ab29202cadd3c
Source dataset
uspto-grants-2010_11
Patent number
US07842703B2

Reaction notes

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