Hydrochloric Acid → HCID 135600032, compound

HRID 1175819Notes

Reaction equation

HRID 1175819 reaction equation
[NH2:1][C:2]1[N:3]([C:16]2[CH:17]=[C:18]([CH:23]=[CH:24][CH:25]=2)[C:19]([O:21]C)=[O:20])[N:4]=[C:5]2[C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[NH:8][C:7](=[O:15])[C:6]=12.[OH-].[Na+].CO.Cl>O.O1CCCC1>[NH2:1][C:2]1[N:3]([C:16]2[CH:17]=[C:18]([CH:23]=[CH:24][CH:25]=2)[C:19]([OH:21])=[O:20])[N:4]=[C:5]2[C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[NH:8][C:7](=[O:15])[C:6]=12

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 135599895HCID 135599895, compound

Product 1

HCID 135600032HCID 135600032, compoundYield 82.2%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of methyl 3-(3-amino-4-oxo-4,5-dihydro-2H-pyrazolo[4,3-c]quinolin-2-yl)benzoate (80 mg), an 1N aqueous sodium hydroxide solution (0.5 ml), methanol (5 ml), tetrahydrofuran (5 ml) and water (2.5 ml) was stirred at 50° C. for 1 hour. The reaction mixture was neutralized with 1N hydrochloric acid. The precipitated solid was collected by filtration, washed with water, and dried to obtain the target compound (63 mg).

Workup

  1. filtrationThe precipitated solid was collected by filtration
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-f52511bb0b1b4761aab76ce54300e8d0
Source dataset
uspto-grants-2010_11
Patent number
US07842701B2

Reaction notes

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