HCID 57498037, compound → 5-Phenyluracil

HRID 1176032Notes

Reaction equation

HRID 1176032 reaction equation
C[O:2][C:3]1[N:8]=[C:7]([O:9]C)[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:5][N:4]=1>Cl>[C:11]1([C:6]2[C:7](=[O:9])[NH:8][C:3](=[O:2])[NH:4][CH:5]=2)[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

3

Reactant 1

HCID 57498037HCID 57498037, compound

Product 1

HCID 2871105-PhenyluracilYield 80%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

2,4-Dimethoxy-5-phenyl-pyrimidine was suspended in 6N HCl and heated to 100 C for 24 h. Solution was cooled in an ice bath to afford title compound as a white solid 119 mg (80% yield). HNMR (500 MHz, dmso): 111.25 (1H, s), 11.15 (1H, d), 7.65 (1H, d), 7.55 (2H, d), 7.35 (2H, m), 7.25 (1H, t).

Workup

  1. temperatureheated to 100 C for 24 h
  2. temperatureSolution was cooled in an ice bath

Sources & evidence

ORD record
ord-8668a78e75e24d279c8e1c721e694c29
Source dataset
uspto-grants-2010_11
Patent number
US07842712B2

Reaction notes

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