1(2H)-Phthalazinone → 1-Chlorophthalazine

HRID 1176186Notes

Reaction equation

HRID 1176186 reaction equation
[C:1]1(=O)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[N:3][NH:2]1.P(Cl)(Cl)([Cl:14])=O>>[Cl:14][C:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[N:3][N:2]=1

Participants

3

Reactant 2

HCID 83941(2H)-PhthalazinoneHCID 24813Phosphorus oxychloride

Product 1

HCID 1607931-Chlorophthalazine

Procedure

Compounds of this invention with Formulae I-VIII also could be prepared as illustrated by the exemplary reaction in Scheme 6. Reaction of phthalazin-1(2H)-one with phosphorus oxychloride produced 1-chlorophthalazine, which was reacted with a substituted aniline, such as N-methyl-4-methoxy-aniline, to produce the substituted 1-anilino-phthalazine.

Workup

  1. customCompounds of this invention with Formulae I-VIII also could be prepared
  2. customas illustrated by the exemplary reaction in Scheme 6

Sources & evidence

ORD record
ord-f4bb1095f40e41158e6b753bd289bf94
Source dataset
uspto-grants-2010_11
Patent number
US07842805B2

Reaction notes

Loading…