1,3-Dibromopropane → 2-(3-Bromopropoxy)-1,3-difluorobenzene

HRID 1176481Notes

Reaction equation

HRID 1176481 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[OH:9].[Br:10][CH2:11][CH2:12][CH2:13]Br>>[Br:10][CH2:11][CH2:12][CH2:13][O:9][C:3]1[C:2]([F:1])=[CH:7][CH:6]=[CH:5][C:4]=1[F:8]

Participants

3

Reactant 2

HCID 80011,3-DibromopropaneHCID 943922,6-Difluorophenol

Product 1

HCID 685004252-(3-Bromopropoxy)-1,3-difluorobenzene

Procedure

Analogously to Example 91b, 2.00 g of 2,6-difluorophenol and 30.7 g of 1,3-dibromopropane are reacted. The title compound is obtained as a colourless oil. Rf=0.70 (1:6 EtOAc-heptane); Rt=4.97.

Sources & evidence

ORD record
ord-5cad48b84bbf45818995d9427d545ce5
Source dataset
uspto-grants-2010_11
Patent number
US07842688B2

Reaction notes

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