反应详情

温度

25 °C

15 g (58.3 mmol) of n-propyl-2-cyano-3-hydroxy-4-[(methyl-sulfanyl)methyl]-2-hexenoate were dissolved in CH2Cl2, and 18 g (0.12 mmol) of POCl3 were added. At 0° C., 24 g (237 mmol) of triethylamine were then added dropwise, and the mixture was stirred at 25° C. for 2 h. The reaction solution was concentrated and the residue was dissolved in acetonitrile. At 0° C., 50 ml (650 mmol) of 25% strength ammonia solution were then added dropwise to this solution, and the mixture was stirred for 1 h.

1. concentrationThe reaction solution was concentrated
2. dissolutionthe residue was dissolved in acetonitrile
3. additionAt 0° C., 50 ml (650 mmol) of 25% strength ammonia solution were then added dropwise to this solution
4. stirringthe mixture was stirred for 1 h.