Phosphate → 6-(4-Bromo-2-methyl-phenylamino)-7-fluoro-3-(4-oxo-butyl)-3H-benzoimidazole-5-carboxylic acid cyclopropylmethoxy-amide

HRID 1176877Notes

Reaction equation

HRID 1176877 reaction equation
[CH:1]1([CH2:4][O:5][NH:6][C:7]([C:9]2[C:24]([NH:25][C:26]3[CH:31]=[CH:30][C:29]([Br:32])=[CH:28][C:27]=3[CH3:33])=[C:23]([F:34])[C:12]3[N:13]=[CH:14][N:15]([CH2:16][CH2:17][CH2:18][CH:19]([OH:22])CO)[C:11]=3[CH:10]=2)=[O:8])[CH2:3][CH2:2]1.C1COCC1.P([O-])([O-])([O-])=O.I([O-])(=O)(=O)=O.[Na+]>C(OCC)(=O)C>[CH:1]1([CH2:4][O:5][NH:6][C:7]([C:9]2[C:24]([NH:25][C:26]3[CH:31]=[CH:30][C:29]([Br:32])=[CH:28][C:27]=3[CH3:33])=[C:23]([F:34])[C:12]3[N:13]=[CH:14][N:15]([CH2:16][CH2:17][CH2:18][CH:19]=[O:22])[C:11]=3[CH:10]=2)=[O:8])[CH2:3][CH2:2]1

Participants

6

Reactant 4

HCID 1061PhosphateHCID 8028TetrahydrofuranHCID 23667635Sodium periodateHCID 865990166-(4-Bromo-2-methyl-phenylamino)-3-(4,5-dihydroxy-pentyl)-7-fluoro-3H-benzoimidazole-5-carboxylic acid cyclopropylmethoxy-amide

Product 1

HCID 866171186-(4-Bromo-2-methyl-phenylamino)-7-fluoro-3-(4-oxo-butyl)-3H-benzoimidazole-5-carboxylic acid cyclopropylmethoxy-amideYield 82.3%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a mixture of 6-(4-Bromo-2-methyl-phenylamino)-3-(4,5-dihydroxy-pentyl)-7-fluoro-3H-benzoimidazole-5-carboxylic acid cyclopropylmethoxy-amide 11m (0.244 g, 0.456 mmol), THF (5 mL) and pH 7 phosphate buffer (3 mL) is added sodium periodate (0.195 g, 0.911 mmol). After 16 hours, the reaction mixture is diluted with ethyl acetate and washed with NaHCO3, and brine. The organic layers is dried (Na2SO4) and concentrated under reduced pressure to give an orange solid. Purification by FCC eluted with 4:1 methylene chloride:MeOH yields 0.189 g (82%) pure desired product as a yellow solid: MS APCI (+) m/z 505, 503 (M+1 Br pattern) detected: MS APCI (−) m/z 503, 501 (M−1 Br pattern) detected.

Workup

  1. washwashed with NaHCO3, and brine
  2. dry with materialThe organic layers is dried (Na2SO4)
  3. concentrationconcentrated under reduced pressure
  4. customto give an orange solid
  5. customPurification by FCC
  6. washeluted with 4:1 methylene chloride

Sources & evidence

ORD record
ord-22cd464802534b9593cccd94716d7d0b
Source dataset
uspto-grants-2010_11
Patent number
US07842816B2

Reaction notes

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