Sodium Hydroxide → HCID 67111612, compound

HRID 1177401Notes

Reaction equation

[C:1]1([C:7]([C:9]2[N:14]=[C:13]3[S:15][C:16]([C:18]([O:20]CC)=[O:19])=[N:17][C:12]3=[CH:11][CH:10]=2)=[CH2:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+:24]>C1COCC1>[C:1]1([C:7]([C:9]2[N:14]=[C:13]3[S:15][C:16]([C:18]([O-:20])=[O:19])=[N:17][C:12]3=[CH:11][CH:10]=2)=[CH2:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Na+:24]

Participants

Conditions

Temperature: 25 °C

Procedure

To a solution of ethyl 5-(1-phenylvinyl)thiazolo[5,4-b]pyridine-2-carboxylate (1.04 g, 3.35 mmol) in THF (12.9 mL) was added sodium hydroxide (1.0N, aq.) (3.35 mL, 3.35 mmol), and the resulting suspension was stirred at 25° C. for 5 min. The reaction solution was subsequently concentrated in vacuo at 25° C. to provide sodium 5-(1-phenylvinyl)thiazolo[5,4-b]pyridine-2-carboxylate as a light-orange solid.

Workup

concentrationThe reaction solution was subsequently concentrated in vacuo at 25° C.

Sources & evidence

ORD record: ord-1396d8daf2324c1fa14bd866947fa770
Source dataset: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07842685B2

Reaction notes

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