反应详情

温度

70 °C

A mixture of 2-(4-(1,3-dioxan-2-yl)-2-fluorophenyl)-6-(1-phenylcyclopropyl)-benzo[d]thiazole (0.061 g, 0.14 mmol) and 5N HCl (3.50 mL, 0.14 mmol) in THF (7.0 mL) was heated to 70° C. for 3 h. The reaction was cooled and concentrated in vacuo, placed in an ice bath, and basified with 5 N aq. NaOH. The solid was collected by filtration, rinsed with water and MeOH, and was dried in vacuo to afford 3-fluoro-4-(6-(1-phenylcyclopropyl)-benzo[d]thiazol-2-yl)benzaldehyde. MS (ESI) m/z: Calculated: 373.1; Observed: 374.0 (M++1).

1. temperatureThe reaction was cooled
2. concentrationconcentrated in vacuo
3. customplaced in an ice bath
4. filtrationThe solid was collected by filtration
5. washrinsed with water and MeOH
6. customwas dried in vacuo