反应详情

温度

115 °C

A slurry of N-(3,6-dichloropyridin-2-yl)pivalamide (1.83 g, 7.41 mmol) in 75 mL 5N aq HCl with water cooled reflux pyridine was heated in a 115° C. bath overnight, to give a clear yellow solution. The reaction mixture was cooled and poured onto ice, and was basified with 10 N NaOH. The resulting white precipitate was extracted with DCM, and the combined organics were dried over anhydrous sodium sulfate, filtered, and concentrated in vauco to give 3,6-dichloropyridin-2-amine as an off-white solid. MS (ESI) m/z: calculated: 162.0; Observed: 163.0 (M++1).

1. customto give a clear yellow solution
2. temperatureThe reaction mixture was cooled
3. additionpoured onto ice
4. extractionThe resulting white precipitate was extracted with DCM
5. dry with materialthe combined organics were dried over anhydrous sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated in vauco