Hydrochloric Acid → HCID 178525799, compound

HRID 1177641Notes

Reaction equation

HRID 1177641 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([NH:26][C@H:27]2[CH2:30][C@H:29]([C:31]([O:33]C)=[O:32])[CH2:28]2)[CH:5]=[CH:6][C:7]=1[C:8]1[S:9][C:10]2[C:15]([N:16]=1)=[CH:14][CH:13]=[C:12]([C:17]1([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:19][CH2:18]1)[N:11]=2.[OH-].[Na+].Cl>C1COCC1>[F:1][C:2]1[CH:3]=[C:4]([NH:26][C@H:27]2[CH2:30][C@H:29]([C:31]([OH:33])=[O:32])[CH2:28]2)[CH:5]=[CH:6][C:7]=1[C:8]1[S:9][C:10]2[C:15]([N:16]=1)=[CH:14][CH:13]=[C:12]([C:17]1([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:18][CH2:19]1)[N:11]=2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178501322HCID 178501322, compound

Product 1

HCID 178525799HCID 178525799, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

Methyl trans-3-((3-fluoro-4-(5-(1-phenylcyclopropyl)[1,3]thiazolo[5,4-b]pyridin-2-yl)phenyl)amino)cyclobutanecarboxylate (2.0 mg, 4.2 μmol) was dissolved in THF (0.422 ml) before 0.1 N sodium hydroxide (169 μl, 17 μmol) was added and stirred for 16 h at ambient temperature. The reaction mixture was acidified with 2 N HCl, diluted with THF, separated, dried over sodium sulfate, and was concentrated to give the title compound. MS (ESI) m/z: Calculated: 459.1; Observed: 460.0 (M++H).

Workup

  1. additionwas added
  2. customseparated
  3. dry with materialdried over sodium sulfate
  4. concentrationwas concentrated

Sources & evidence

ORD record
ord-f90aba9818cf4099b80cd9b4d43fdf2f
Source dataset
uspto-grants-2010_11
Patent number
US07842685B2

Reaction notes

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