反应详情

温度

65 °C

Methyl 2-(5-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)isoindolin-2-yl)acetate (17 mg, 0.039 mmol) was dissolved in THF (308 μL) and water (77 μL) before lithium hydroxide monohydrate (1 mg, 0.039 mmol) was added and stirred at 65° C. for 2 h. The reaction mixture was concentrated, acidified with 1 N HCl, and filtered. The solid was dissolved in DMSO and eluted through the frit to give the title compound after concentration. MS (ESI) m/z: Calculated: 427.1; Observed: 427.9 (M++H).

1. concentrationThe reaction mixture was concentrated
2. filtrationfiltered
3. dissolutionThe solid was dissolved in DMSO
4. washeluted through the frit