反应详情

To a solution of 2-(di-tert-butoxycarbonylamino)-acrylic acid methyl ester (1.0 g, 3.0 mmol) in acetonitrile (10 mL) was added piperidin-4-ol (0.33 g, 1.1 equiv). A gentle stream of nitrogen was placed over the reaction while it stirred overnight. The crude oil which resulted was dissolved in ethyl acetate, washed with water, then brine, dried over magnesium sulfate, and concentrated to give 1.38 g (quant.) as an oil which was used without purification. Mass spec.: 403.42 (MH)+.

1. customA gentle stream of nitrogen was placed over the reaction while it
2. customThe crude oil which resulted
3. washwashed with water
4. dry with materialbrine, dried over magnesium sulfate
5. concentrationconcentrated
6. customto give 1.38 g (quant.) as an oil which
7. customwas used without purification