HCID 58864221, compound → HCID 58864393, compound

HRID 1177760Notes

Reaction equation

HRID 1177760 reaction equation
[CH2:1]([O:3][C:4](=[O:24])[CH:5]([NH:14][C:15]1[CH:16]=[C:17]2[C:21](=[CH:22][CH:23]=1)[NH:20][N:19]=[CH:18]2)[CH2:6][C:7]([O:9]C(C)(C)C)=[O:8])[CH3:2]>C(Cl)Cl.FC(F)(F)C(O)=O.C(OCC)(=O)C>[CH2:1]([O:3][C:4](=[O:24])[CH:5]([NH:14][C:15]1[CH:16]=[C:17]2[C:21](=[CH:22][CH:23]=1)[NH:20][N:19]=[CH:18]2)[CH2:6][C:7]([OH:9])=[O:8])[CH3:2]

Participants

5

Reactant 1

HCID 58864221HCID 58864221, compound

Product 1

HCID 58864393HCID 58864393, compound

Reagents, catalysts & solvents 3

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolventHCID 8857Ethyl AcetateSolvent

Procedure

A stirred solution of 2-(1H-indazol-5-ylamino)-succinic acid 4-tert-butyl ester 1-ethyl ester (123.6 mg, 0.37 mmol) in methylene chloride (2 mL) and trifluoroacetic acid (0.5 mL) was stirred at room temperature overnight. The reaction mixture was then diluted with ethyl acetate and washed with saturated ammonium chloride solution, water and brine. The organic layer was dried and concentrated to give a dark green oil: LC/MS: tR=0.643 min, 278.19 (MH)+.

Workup

  1. washwashed with saturated ammonium chloride solution, water and brine
  2. customThe organic layer was dried
  3. concentrationconcentrated
  4. customto give a dark green oil

Sources & evidence

ORD record
ord-fceb58804044423d87d23928414bd399
Source dataset
uspto-grants-2010_11
Patent number
US07842808B2

Reaction notes

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