Hydrochloric Acid → HCID 131726616, compound

HRID 1178304Notes

Reaction equation

HRID 1178304 reaction equation
[C:1](Cl)(=[O:5])[CH2:2][CH2:3][CH3:4].[Al+3].[Cl-].[Cl-].[Cl-].[CH3:11][O:12][C:13]1[CH:14]=[C:15]2[O:36][C:35]([CH3:38])([CH3:37])[CH:34]=[CH:33][C:16]2=[C:17]2[C:26]=1[C:25](=[O:27])[C:24]1[C:19](=[CH:20][CH:21]=[C:22]3[CH:31]=[CH:30][CH:29]=[CH:28][C:23]3=1)[N:18]2[CH3:32].Cl>ClCCl>[C:1]([C:34]1[C:35]([CH3:37])([CH3:38])[O:36][C:15]2[C:16](=[C:17]3[C:26](=[C:13]([O:12][CH3:11])[CH:14]=2)[C:25](=[O:27])[C:24]2[C:19](=[CH:20][CH:21]=[C:22]4[CH:31]=[CH:30][CH:29]=[CH:28][C:23]4=2)[N:18]3[CH3:32])[CH:33]=1)(=[O:5])[CH2:2][CH2:3][CH3:4]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 8855Butyryl chlorideHCID 6451240Aluminum(III) ChlorideHCID 11485551HCID 11485551, compound

Product 1

HCID 131726616HCID 131726616, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A mixture of 0.81 mmol of butyryl chloride and 0.673 mmol of AlCl3 in 2 ml of anhydrous dichloromethane is added, in small portions, to 0.135 mmol of the product of Example 3 in 2 ml of dichloromethane at 0° C. The reaction mixture is stirred for 4 hours at ambient temperature and then poured into a 10% HCl solution. After conventional treatment of the organic phases and evaporation thereof under reduced pressure, chromatography of the residue over silica gel (dichloromethane/methanol) allows the expected product to be isolated.

Workup

  1. customAfter conventional treatment of the organic phases and evaporation
  2. customto be isolated

Sources & evidence

ORD record
ord-08a46057839c4f02accda0cdc294a56b
Source dataset
uspto-grants-2007_10
Patent number
US07276512B2

Reaction notes

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