Ethanol → 7153-28-8

HRID 1178319Notes

Reaction equation

HRID 1178319 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[Cl:10])[CH:5]=O.[C-]#N.[K+].[C:14](=[O:17])([O-])[O-].[NH4+:18].[NH4+:19].[CH2:20]([OH:22])C>O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:5]2[NH:19][C:20](=[O:22])[NH:18][C:14]2=[O:17])[CH:7]=[CH:8][C:9]=1[Cl:10]

Participants

6

Reactant 4

HCID 702EthanolHCID 9032Potassium CyanideHCID 227103,4-DichlorobenzaldehydeHCID 517111Ammonium Carbonate

Product 1

HCID 956667153-28-8

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
62.5 °C

Procedure

3,4-Dichlorobenzaldehyde (500 g), potassium cyanide (279 g), and ammonium carbonate (824 g) were dissolved in a solvent mixture of ethanol (1.25 L) and water (1.25 L), followed by stirring at an internal temperature of 60 to 65° C. for 1 hour. The reaction mixture was left to cool to room temperature, and ethanol was evaporated under reduced pressure. Water was added to the residue, followed by filtration and drying, to thereby give the title compound (900 g). The title compound was used in the next step without further purification.

Workup

  1. waitThe reaction mixture was left
  2. temperatureto cool to room temperature
  3. customethanol was evaporated under reduced pressure
  4. additionWater was added to the residue
  5. filtrationfollowed by filtration
  6. customdrying

Sources & evidence

ORD record
ord-348a1da9223a4e3c8d6e761458388392
Source dataset
uspto-grants-2007_10
Patent number
US07276511B2

Reaction notes

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