反应详情

LiOH (1.41 g, 33.6 mmol) in H2O (16.5 mL) was added to a stirring solution of 2-chloro-N-[1-(methoxycarbonylmethyl)-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl]-6H-thieno[2,3-b]pyrrole-5-carboxamide (Example 1; 7.00 g, 16.8 mmol) in THF (88 mL) and the reaction was stirred for 2 h. The reaction was quenched by addition of 1M aqueous HCl (200 mL) and EtOAc (400 mL) and the organic layer was dried (MgSO4), filtered and evaporated. The resultant white foam was triturated with hot Et2O (100 mL) cooled, filtered and dried to afford the title compound (6.00 g, 89%) as a white solid.

1. customThe reaction was quenched by addition of 1M aqueous HCl (200 mL) and EtOAc (400 mL)
2. dry with materialthe organic layer was dried (MgSO4)
3. filtrationfiltered
4. customevaporated
5. customThe resultant white foam was triturated with hot Et2O (100 mL)
6. temperaturecooled
7. filtrationfiltered
8. customdried