Indole → HCID 23118670, compound

HRID 1178734Notes

Reaction equation

[CH:1]1[C:14]2[C:5](=[N:6][CH:7]=[C:8]3[C:13]=2[CH:12]=[CH:11][CH:10]=[CH:9]3)[CH:4]=[CH:3][CH:2]=1.[C:15](Cl)(=[O:19])[CH:16]([CH3:18])[CH3:17].[NH:21]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH:23]=[CH:22]1>>[NH:21]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[C:23]([CH:7]2[C:8]3[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=3)[C:14]3[CH:1]=[CH:2][CH:3]=[CH:4][C:5]=3[N:6]2[C:15](=[O:19])[CH:16]([CH3:18])[CH3:17])=[CH:22]1

Participants

Reactant 3

HCID 798Indole

HCID 9189Phenanthridine

HCID 62325Isobutyryl chloride

Product 1

HCID 23118670HCID 23118670, compound

Procedure

1-[6-(1H-Indol-3-yl)-6H-phenanthridin-5-yl]-2-methyl-propan-1-one was prepared from phenanthridine, isobutyryl chloride, and indole according to GP 2. Yield, 18%. (+)-ESI-MS: m/z=367 [M+H]+, 250 [M-indole+H]+, 180.

Workup

customYield

Sources & evidence

ORD record: ord-4cbb810cb00a453cb28cf9554be3a073
Source dataset: uspto-grants-2007_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07276606B2

Reaction notes

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