Hydrochloric Acid → HCID 68526195, compound

HRID 1178898Notes

Reaction equation

HRID 1178898 reaction equation
[ClH:1].[CH:2]1([C:8]2([CH2:23][S:24][CH3:25])[CH2:14][CH:13]3[N:15](C(OC(C)(C)C)=O)[CH:10]([CH2:11][CH2:12]3)[CH2:9]2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1>O1CCOCC1>[Cl-:1].[CH:2]1([C:8]2([CH2:23][S:24][CH3:25])[CH2:14][CH:13]3[NH2+:15][CH:10]([CH2:11][CH2:12]3)[CH2:9]2)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58695800Tert-butyl 3-cyclohexyl-3-[(methylthio)methyl]-8-azabicyclo[3.2.1]octane-8-carboxylate

Product 1

HCID 68526195HCID 68526195, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of 4.0 N HCl in dioxane (20.0 mL) was added tert-butyl 3-cyclohexyl-3-[(methylthio)methyl]-8-azabicyclo[3.2.1]octane-8-carboxylate (3-5) (0.870 g, 2.46 mmol). The mixture was stirred at room temperature for three hours and the volatiles were removed under vacuum to give (3-6) as a pale solid.

Workup

  1. customthe volatiles were removed under vacuum

Sources & evidence

ORD record
ord-1277d9c0b5654b00b094e10817c71cc9
Source dataset
uspto-grants-2007_10
Patent number
US07276520B2

Reaction notes

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